What does this research mean for the field?

Preoperative systemic inflammatory indices (higher NLR and PLR, lower LMR) are significantly associated with ovarian tumor malignancy independent of age and CA-125, but offer only modest individual diagnostic discrimination and should be used as complementary biomarkers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association and diagnostic accuracy of preoperative systemic inflammatory indices in distinguishing malignant from non-malignant ovarian tumors.

August 23, 2026MedicinaOpen Access

Preoperative Inflammatory Markers as Predictors of Ovarian Tumor Malignancy: A Retrospective Diagnostic Study

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Authors

DGDenis GruberVictor Babeș University of Medicine and Pharmacy Timișoara ABAnca M. BînăClinical Emergency Hospital Bucharest AAAhmed Abu-AwwadSpitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara

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Implication

Retrospective observational study reveals elevated inflammatory ratios associate with malignancy in ovarian tumors, indicating utility as complementary diagnostic biomarkers.

Key Points

To evaluate the association and diagnostic accuracy of preoperative systemic inflammatory indices in distinguishing malignant from non-malignant ovarian tumors.
Retrospective, single-center observational study of N=780 adult female patients surgically treated for ovarian tumors between January 2020 and December 2025.
Calculated neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and lymphocyte-to-monocyte (LMR) ratios from routine preoperative complete blood counts.
Evaluated independent predictive associations and diagnostic capacity via multivariable logistic regression adjusted for age and CA-125, alongside ROC curve analyses.
Higher NLR (OR = 1.79, 95% CI: 1.41–2.27, p < 0.001) and PLR (OR = 1.43, 95% CI: 1.17–1.75, p = 0.001) remained significantly associated with malignant tumors, whereas higher LMR was inversely associated (OR = 0.66, 95% CI: 0.52–0.85, p = 0.001).
ROC analysis demonstrated moderate discriminative capability for both NLR (AUC = 0.72) and PLR (AUC = 0.72), while LMR exhibited lower performance (AUC = 0.64).

Cite This Study

Gruber et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadd57677a341144464eb https://doi.org/10.3390/medicina62081613

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Implication

Retrospective observational study reveals elevated inflammatory ratios associate with malignancy in ovarian tumors, indicating utility as complementary diagnostic biomarkers.

Preoperative Inflammatory Markers as Predictors of Ovarian Tumor Malignancy: A Retrospective Diagnostic Study

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Implication

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Cite This Study

Preoperative Inflammatory Markers as Predictors of Ovarian Tumor Malignancy: A Retrospective Diagnostic Study

Discussion

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Implication

Key Points

Cite This Study

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