What does this research mean for the field?

Pre-calving faecal microbiota composition in dairy cattle is associated with post-calving systemic inflammatory responses and specific cytokine profiles, including IL-17A, IL-1α, and IL-1β. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate systemic immune responsiveness and explore associations between faecal microbiota composition and cytokine profiles in dairy cows around the calving period.

August 23, 2026Scientific ReportsOpen Access

Faecal microbiota composition associates with systemic inflammatory marker and cytokine profiles in periparturient dairy cattle

View Full Paper

Ask AI

Bookmark

Authors

LALisa Arnalot MMMarine Milhes BGBlandine Gausserès

Discussion

Member takes

Overview

Cohort study reveals gut microbiota composition correlates with inflammatory cytokine profiles in periparturient dairy cattle, indicating pre-calving microbes may shape post-calving immunity.

Key Points

To evaluate systemic immune responsiveness and explore associations between faecal microbiota composition and cytokine profiles in dairy cows around the calving period.
Collected blood and faecal samples before and after parturition from a cohort of 411 dairy cows across 25 commercial dairy farms.
Assessed cytokine and chemokine release following ex vivo whole-blood lipopolysaccharide stimulation via a 15-plex assay, and profiled faecal microbiota using 16S rRNA metabarcoding.
Identified four distinct cytokine secretion profiles around calving; while broad clusters did not differentiate by microbiota, faecal microbiota explained up to 9.4% of variance in individual cytokines such as CCL3.
Found specific taxa associations with immune markers, where higher abundance of Clostridium sensu stricto 1 associated with elevated IL-17A and lower Monoglobus levels associated with elevated IL-1α.

Cite This Study

Arnalot et al. (2026) studied this question.

synapsesocial.com/papers/6a8aade47677a3411444669c https://doi.org/10.1038/s41598-026-64969-9

View Full Paper

Ask AI

Bookmark

August 23, 2026Scientific ReportsOpen Access

Faecal microbiota composition associates with systemic inflammatory marker and cytokine profiles in periparturient dairy cattle

View Full Paper

Ask AI

Bookmark

Authors

LALisa Arnalot MMMarine Milhes BGBlandine Gausserès

Discussion

Member takes

Overview

Cohort study reveals gut microbiota composition correlates with inflammatory cytokine profiles in periparturient dairy cattle, indicating pre-calving microbes may shape post-calving immunity.

Key Points

To evaluate systemic immune responsiveness and explore associations between faecal microbiota composition and cytokine profiles in dairy cows around the calving period.
Collected blood and faecal samples before and after parturition from a cohort of 411 dairy cows across 25 commercial dairy farms.
Assessed cytokine and chemokine release following ex vivo whole-blood lipopolysaccharide stimulation via a 15-plex assay, and profiled faecal microbiota using 16S rRNA metabarcoding.
Identified four distinct cytokine secretion profiles around calving; while broad clusters did not differentiate by microbiota, faecal microbiota explained up to 9.4% of variance in individual cytokines such as CCL3.
Found specific taxa associations with immune markers, where higher abundance of Clostridium sensu stricto 1 associated with elevated IL-17A and lower Monoglobus levels associated with elevated IL-1α.

Cite This Study

Arnalot et al. (2026) studied this question.

synapsesocial.com/papers/6a8aade47677a3411444669c https://doi.org/10.1038/s41598-026-64969-9

View Full Paper

Ask AI

Bookmark