What does this research mean for the field?

An immediate postoperative thromboelastography (TEG) coagulation index of -1.75, along with specific thresholds for other TEG parameters, provides high predictive accuracy for major bleeding following on-pump cardiac surgery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To establish optimal thromboelastography parameter thresholds for predicting major postoperative hemorrhage in patients undergoing cardiopulmonary bypass during cardiac surgery.

August 23, 2026Seminars in Thrombosis and HemostasisOpen Access

Thromboelastography Parameters Thresholds for Optimal Prediction of Major Bleeding after On-Pump Cardiac Surgery

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Authors

ZXZhili XuZhejiang Chinese Medical University XTXinchen TaoSecond Affiliated Hospital of Zhejiang University HCHan CaoSecond Hospital of Shandong University

Discussion

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Implication

Retrospective study shows postoperative thromboelastography parameters predict major bleeding in on-pump cardiac surgery, indicating a reliable early warning tool.

Key Points

To establish optimal thromboelastography parameter thresholds for predicting major postoperative hemorrhage in patients undergoing cardiopulmonary bypass during cardiac surgery.
Retrospective analysis of 3,810 cardiac surgery patients requiring cardiopulmonary bypass, divided into major bleeding (≥1,000 mL chest tube drainage within 24 hours; n = 245) and non-major bleeding (n = 3,565) groups.
Logistic regression and receiver operating characteristic curve analyses were used to identify independent risk factors and evaluate the sensitivity and specificity of predictive parameter thresholds.
An immediate postoperative coagulation index threshold of −1.75 predicted major bleeding with 78.5% sensitivity (95% CI: 73.3–83.8%), 60.0% specificity (95% CI: 58.4–61.7%), and an OR of 4.55 (95% CI: 3.24–6.38).
Other immediate postoperative parameters showed predictive capability, including kinetics time (AUC = 0.71), reaction time (AUC = 0.70), α-angle (AUC = 0.69), maximum amplitude (AUC = 0.67), and post-bypass maximum amplitude of 58.05 mm.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadf37677a341144467d7 https://doi.org/10.1055/a-2924-0114

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August 23, 2026Seminars in Thrombosis and HemostasisOpen Access

Thromboelastography Parameters Thresholds for Optimal Prediction of Major Bleeding after On-Pump Cardiac Surgery

View Full Paper

Ask AI

Bookmark

Authors

ZXZhili XuZhejiang Chinese Medical University XTXinchen TaoSecond Affiliated Hospital of Zhejiang University HCHan CaoSecond Hospital of Shandong University

Discussion

Member takes

Implication

Retrospective study shows postoperative thromboelastography parameters predict major bleeding in on-pump cardiac surgery, indicating a reliable early warning tool.

Key Points

To establish optimal thromboelastography parameter thresholds for predicting major postoperative hemorrhage in patients undergoing cardiopulmonary bypass during cardiac surgery.
Retrospective analysis of 3,810 cardiac surgery patients requiring cardiopulmonary bypass, divided into major bleeding (≥1,000 mL chest tube drainage within 24 hours; n = 245) and non-major bleeding (n = 3,565) groups.
Logistic regression and receiver operating characteristic curve analyses were used to identify independent risk factors and evaluate the sensitivity and specificity of predictive parameter thresholds.
An immediate postoperative coagulation index threshold of −1.75 predicted major bleeding with 78.5% sensitivity (95% CI: 73.3–83.8%), 60.0% specificity (95% CI: 58.4–61.7%), and an OR of 4.55 (95% CI: 3.24–6.38).
Other immediate postoperative parameters showed predictive capability, including kinetics time (AUC = 0.71), reaction time (AUC = 0.70), α-angle (AUC = 0.69), maximum amplitude (AUC = 0.67), and post-bypass maximum amplitude of 58.05 mm.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadf37677a341144467d7 https://doi.org/10.1055/a-2924-0114

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