Toward Complex Polyketide Biosynthesis in Yarrowia lipolytica via Metabolic Reprogramming

Q: What does this research mean for the field?

Yarrowia lipolytica has the potential to serve as a programmable, industrially viable platform for complex polyketide production through metabolic reprogramming, provided current limitations are addressed. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kian Ghaempanah; Sohee Son; Ju Young Lee

doi:10.4014/jmb.2606.06035

August 21, 2026Journal of Microbiology and Biotechnology

Toward Complex Polyketide Biosynthesis in Yarrowia lipolytica via Metabolic Reprogramming

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Key Points

To evaluate current limitations and metabolic engineering strategies for developing Yarrowia lipolytica into a programmable, industrial platform for complex polyketide biosynthesis.
Reviewed cellular and metabolic pathways involved in precursor supply, cofactor balance, and polyketide assembly in Yarrowia lipolytica.
Critically evaluated synthetic biology tools and pathway engineering strategies used to overcome host biosynthetic bottlenecks.
Identified key metabolic constraints limiting precursor flux and heterologous enzyme efficiency in complex polyketide pathways.
Established engineering frameworks to optimize lipid metabolism, cellular energy balance, and yield for sustainable industrial-scale production.

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Implication

Review highlights metabolic reprogramming strategies for complex polyketides in Yarrowia lipolytica, indicating pathways to an industrially viable biomanufacturing platform.

Abstract

, critically assess current limitations, and explore future directions to establish this organism as a programmable, industrially viable platform for polyketide production.

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Cite This Study

Ghaempanah et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae007677a34114446a85 https://doi.org/10.4014/jmb.2606.06035

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Toward Complex Polyketide Biosynthesis in Yarrowia lipolytica via Metabolic Reprogramming

Key Points

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Implication

Abstract

Discussion

Cite This Study

Toward Complex Polyketide Biosynthesis in Yarrowia lipolytica via Metabolic Reprogramming

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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