Aging is associated with changes in systemic homeostasis, intestinal barrier integrity, and brain function.This study investigated the effects of Lactiplantibacillus plantarum HY7715 on aging-related alterations in a D-galactose-induced accelerated aging mouse model.Male C57BL/6J mice were administered D-galactose for 8 weeks and orally treated with live or heat-killed HY7715.D-galactose increased circulating advanced glycation end products (AGEs), blood-brain barrier (BBB) permeability, hippocampal inflammation, and aging-related molecular changes, while impairing cortical and colonic tight junctionassociated markers.Both live and heat-killed HY7715 reduced serum AGE levels, Evans blue leakage, and hippocampal inflammatory responses, while restoring CLDN5 immunoreactivity, tight junction-associated gene expression, and antioxidant-related gene expression.HY7715 also attenuated senescence-and apoptosis-related changes in the hippocampus and colonic tight junction-and inflammation-related gene expression changes.Gut microbiota analysis showed taxon-specific changes following HY7715 treatment, including significant increases in Bifidobacterium in both HY7715-treated groups, whereas live HY7715 was associated with significant changes in microbial community structure.Several microbial taxa were correlated with serum AGEs, BBB permeability, and neuroinflammation-related parameters.Together, these results show that both live and heat-killed HY7715 attenuated multiple aging-related changes in the Dgalactose-induced accelerated aging model, accompanied by changes in gut microbiota composition.
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Baik et al. (2026) studied this question.
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