What does this research mean for the field?

The Ayurvedic concept of Agni represents a multidimensional model of biological transformation that can be functionally correlated with contemporary physiological processes of digestion, cellular metabolism, and energy homeostasis. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To critically evaluate the classical Ayurvedic concept of Agni and map its functional relationships to contemporary principles of digestion, intermediary metabolism, and tissue-level homeostasis.

August 23, 2026Open Access

Agni and Metabolism: An Ayurvedic–Physiological Correlation

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To critically evaluate the classical Ayurvedic concept of Agni and map its functional relationships to contemporary principles of digestion, intermediary metabolism, and tissue-level homeostasis.
Conducted a narrative conceptual review of classical Ayurvedic texts, including Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya.
Integrated classical concepts with modern biomedical literature on gastrointestinal physiology, biochemistry, nutrition, circadian rhythms, and metabolic health.
Correlated the thirteen classical Agnis to distinct physiological tiers: Jatharagni maps to gastrointestinal digestion and enzyme activity, Bhutagni to intermediate nutrient processing, and Dhatvagni to tissue-specific nutrient utilization.
Maligned functional states of Agni (Samagni, Mandagni, Tikshnagni, and Vishamagni) and the formation of Ama qualitatively parallel biomedical disruptions in nutrient transport, hormonal regulation, cellular metabolism, and energy homeostasis.

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Implication

Narrative review reveals functional parallels between Ayurvedic Agni and modern gastrointestinal and metabolic physiology, highlighting opportunities for biomarker and metabolomic integration.

Cite This Study

Sapcota et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae0f7677a34114446c85 https://doi.org/10.5281/zenodo.22023144

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Implication

Narrative review reveals functional parallels between Ayurvedic Agni and modern gastrointestinal and metabolic physiology, highlighting opportunities for biomarker and metabolomic integration.

Agni and Metabolism: An Ayurvedic–Physiological Correlation

Key Points

Discussion

Implication

Cite This Study

Agni and Metabolism: An Ayurvedic–Physiological Correlation

Key Points

Discussion

Implication

Cite This Study

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