What does this research mean for the field?

Vitamin D deficiency management should shift from untargeted population supplementation to clinically indicated assessment and targeted repletion for high-risk individuals, primarily to support musculoskeletal health. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To clarify the clinical distinction between routine, empiric population-wide supplementation and monitored repletion of documented vitamin D deficiency in high-risk individuals.

August 23, 2026NutrientsOpen Access

From Routine Supplementation to Targeted Repletion: Vitamin D Deficiency in UVB-Constrained, Pollution-Exposed, and Ageing Populations—Musculoskeletal and Extra-Skeletal Perspectives

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Authors

YYYonghyun YoonHallym University JHJihyo HwangHallym University Kangnam Sacred Heart Hospital JKJung Youn KimHallym University Kangnam Sacred Heart Hospital

Discussion

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Implication

Narrative review reveals targeted vitamin D repletion benefits high-risk and ageing populations primarily for musculoskeletal health, indicating routine empiric supplementation is unwarranted.

Key Points

To clarify the clinical distinction between routine, empiric population-wide supplementation and monitored repletion of documented vitamin D deficiency in high-risk individuals.
Conducted a narrative review of PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library through June 2026.
Synthesized findings based on baseline and achieved 25-hydroxyvitamin D [25(OH)D] concentrations, dosing schedule, route, body composition, endpoints, and population risk profiles.
Musculoskeletal endpoints—including osteomalacia, muscle function, osteoporosis management, and fracture vulnerability—provide the primary clinical rationale for targeted repletion in deficient patients.
Short-term trials demonstrate broadly equivalent biochemical repletion across moderate daily, weekly, or monthly oral regimens, but equivalence is not established for long-term clinical outcomes or large intermittent boluses.
Evidence supporting extra-skeletal benefits remains weak in randomized trials, showing that target levels above standard skeletal adequacy thresholds remain investigational.

Cite This Study

Yoon et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae207677a34114446eb8 https://doi.org/10.3390/nu18162736

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Implication

Narrative review reveals targeted vitamin D repletion benefits high-risk and ageing populations primarily for musculoskeletal health, indicating routine empiric supplementation is unwarranted.

From Routine Supplementation to Targeted Repletion: Vitamin D Deficiency in UVB-Constrained, Pollution-Exposed, and Ageing Populations—Musculoskeletal and Extra-Skeletal Perspectives

Discussion

Member takes

Implication

Key Points

Cite This Study

From Routine Supplementation to Targeted Repletion: Vitamin D Deficiency in UVB-Constrained, Pollution-Exposed, and Ageing Populations—Musculoskeletal and Extra-Skeletal Perspectives

Discussion

Member takes

Implication

Key Points

Cite This Study

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