What does this research mean for the field?

Adult-onset presumed congenital syphilitic interstitial keratitis can present with refractory inflammation requiring prolonged multidisciplinary management and specialty contact lenses for visual rehabilitation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To report a rare case of adult-onset presumed congenital syphilitic interstitial keratitis and illustrate the multidisciplinary clinical and visual management required.

August 23, 2026Eye & Contact Lens Science & Clinical Practice

A Case of Adult-onset Presumed Congenital Syphilitic Keratitis: A Multidisciplinary Management Approach

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Authors

MZMi Zhou TSThomas L. Steinemann

Discussion

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Overview

Case report shows refractory corneal inflammation and perforation in adult-onset congenital syphilitic keratitis, highlighting the role of multidisciplinary care and specialty lenses.

Key Points

To report a rare case of adult-onset presumed congenital syphilitic interstitial keratitis and illustrate the multidisciplinary clinical and visual management required.
Clinical and serologic evaluation of a 28-year-old male presenting with an 11-year history of progressive bilateral ocular redness, tearing, and visual decline.
Implementation of a multidisciplinary treatment regimen including intravenous penicillin G, topical corticosteroids, tectonic patch grafting, and rigid corneal and scleral contact lens fitting.
Serologic analysis revealed positive treponemal and negative nontreponemal antibodies, confirming late congenital syphilitic interstitial keratitis.
The clinical course involved refractory inflammation, progressive stromal scarring, and corneal perforation requiring tectonic patch grafting despite antibiotic and corticosteroid therapy.
Functional visual rehabilitation was achieved through long-term collaborative management utilizing rigid corneal and scleral contact lenses.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae207677a34114446efb https://doi.org/10.1097/icl.0000000000001304

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August 23, 2026Eye & Contact Lens Science & Clinical Practice

A Case of Adult-onset Presumed Congenital Syphilitic Keratitis: A Multidisciplinary Management Approach

View Full Paper

Ask AI

Bookmark

Authors

MZMi Zhou TSThomas L. Steinemann

Discussion

Member takes

Overview

Case report shows refractory corneal inflammation and perforation in adult-onset congenital syphilitic keratitis, highlighting the role of multidisciplinary care and specialty lenses.

Key Points

To report a rare case of adult-onset presumed congenital syphilitic interstitial keratitis and illustrate the multidisciplinary clinical and visual management required.
Clinical and serologic evaluation of a 28-year-old male presenting with an 11-year history of progressive bilateral ocular redness, tearing, and visual decline.
Implementation of a multidisciplinary treatment regimen including intravenous penicillin G, topical corticosteroids, tectonic patch grafting, and rigid corneal and scleral contact lens fitting.
Serologic analysis revealed positive treponemal and negative nontreponemal antibodies, confirming late congenital syphilitic interstitial keratitis.
The clinical course involved refractory inflammation, progressive stromal scarring, and corneal perforation requiring tectonic patch grafting despite antibiotic and corticosteroid therapy.
Functional visual rehabilitation was achieved through long-term collaborative management utilizing rigid corneal and scleral contact lenses.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae207677a34114446efb https://doi.org/10.1097/icl.0000000000001304

Also Consider

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