Individualized Nutritional and Microbiome-Oriented Management of Food Allergy-Associated Atopic Dermatitis in Children: A Prospective Real-World Observational Cohort Study
Prospective cohort study reveals marked symptom reduction following personalized nutritional and microbiome therapy in children with eczema, indicating value as an adjunctive strategy.
Key Points
To assess clinical outcomes of an integrated, personalized nutritional and microbiome-directed management strategy in pediatric patients with food allergy-associated atopic dermatitis in real-world practice.
Conducted a prospective, two-center, real-world observational cohort study of 85 children (median age, 11 months) diagnosed with atopic dermatitis and confirmed IgE- or non-IgE-mediated food allergies.
Administered individualized interventions consisting of elimination diets, standard topical therapies, microbiome-targeted therapies, and nutritional supplementation based on patient-specific profiles.
Evaluated disease severity via the Scoring Atopic Dermatitis (SCORAD) index at baseline and at approximately 1-month and 3-month follow-up visits.
Disease severity decreased significantly during follow-up, demonstrating a mean relative SCORAD reduction of 51.6%, with 63.5% of children achieving a SCORAD50 response.
Cow’s milk, egg, and wheat were identified as predominant allergens, with 69.4% of the cohort presenting with polyallergy.
Baseline SCORAD served as the strongest independent predictor of improvement; gut dysbiosis correlated with polyallergy but lost independent predictive value after adjusting for baseline severity.