What does this research mean for the field?

While pediatric kidney transplantation achieves high short-term graft survival (94.6% at 1 year), long-term survival declines significantly (59.5% at 10 years) due to risk factors including acute rejection, delayed graft function, infections, and non-adherence. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate short- and long-term graft survival outcomes and systematically analyze the primary clinical, immunological, and surgical risk factors driving graft failure in pediatric kidney transplant recipients.

August 23, 2026ChildrenOpen Access

Pediatric Kidney Transplantation: A Systematic Review

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Authors

NANoor Sadiq Almoosawe FAFatima Majid Alezairej SASultan Alsalami

Discussion

Member takes

Overview

Systematic review reveals 1-year pediatric kidney graft survival of 94.6% dropping to 59.5% at 10 years, highlighting the need to address rejection, infections, and medication non-adherence.

Key Points

To evaluate short- and long-term graft survival outcomes and systematically analyze the primary clinical, immunological, and surgical risk factors driving graft failure in pediatric kidney transplant recipients.
Searched the PubMed database, yielding 289 initial records.
Screened 108 full-text articles for eligibility and synthesized data from 35 high-quality included studies.
Synthesized 1-year pediatric graft survival was 94.60%, which declined steadily to 59.50% at the 10-year follow-up.
Major immunological and procedural drivers of graft failure included acute rejection episodes, delayed graft function, specific donor characteristics, and early surgical vascular thrombosis.
Post-transplant infections occurred in approximately 45% of patients, and adolescent non-adherence to immunosuppressive therapy was strongly linked to late graft loss.

Cite This Study

Almoosawe et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae337677a34114447065 https://doi.org/10.3390/children13081122

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August 23, 2026ChildrenOpen Access

Pediatric Kidney Transplantation: A Systematic Review

View Full Paper

Ask AI

Bookmark

Authors

NANoor Sadiq Almoosawe FAFatima Majid Alezairej SASultan Alsalami

Discussion

Member takes

Overview

Systematic review reveals 1-year pediatric kidney graft survival of 94.6% dropping to 59.5% at 10 years, highlighting the need to address rejection, infections, and medication non-adherence.

Key Points

To evaluate short- and long-term graft survival outcomes and systematically analyze the primary clinical, immunological, and surgical risk factors driving graft failure in pediatric kidney transplant recipients.
Searched the PubMed database, yielding 289 initial records.
Screened 108 full-text articles for eligibility and synthesized data from 35 high-quality included studies.
Synthesized 1-year pediatric graft survival was 94.60%, which declined steadily to 59.50% at the 10-year follow-up.
Major immunological and procedural drivers of graft failure included acute rejection episodes, delayed graft function, specific donor characteristics, and early surgical vascular thrombosis.
Post-transplant infections occurred in approximately 45% of patients, and adolescent non-adherence to immunosuppressive therapy was strongly linked to late graft loss.

Cite This Study

Almoosawe et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae337677a34114447065 https://doi.org/10.3390/children13081122

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