Case series reveals clinical and serial MRI characteristics of COVID-19-associated cerebral white matter injury in neonates, highlighting potential risks to the developing nervous system.
Since the COVID-19 pandemic began, its characteristic of multisystem involvement has been gradually recognized, including neurologic involvement.In adults and older children, neurologic symptoms are common: most report headache, anosmia or fatigue, while a few develop seizures, encephalitis or cerebral oedema [1].However, reports on COVID-19-associated brain injury in neonates are extremely limited.Only a small number of case reports exist [2][3][4][5][6][7][8][9], and systemic data on imaging and long-term outcomes are lacking.Here we report four neonates with COVID-19-associated white matter injury, describe their clinical features, serial MRI findings and follow-up results to explore the impact of COVID-19 infection on the neonatal nervous system.
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Chen et al. (2026) studied this question.
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