What question did this study set out to answer?

To determine whether corticosterone mediates the systemic inflammatory and metabolic disruptions provoked by acute ozone inhalation.

April 1, 2016Toxicological SciencesOpen Access

Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways

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Authors

ETErrol M. ThomsonHealth Canada SPShinjini PalHealth Canada JGJosée GuénetteHealth Canada

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Implication

Animal experiment demonstrates ozone alters inflammatory and metabolic pathways via corticosterone in rats, indicating stress hormones mediate systemic air pollutant toxicity.

Key Points

To determine whether corticosterone mediates the systemic inflammatory and metabolic disruptions provoked by acute ozone inhalation.
Treated male Fischer-344 rats with the 11β-hydroxylase inhibitor metyrapone (0, 50, or 150 mg/kg) or exogenous corticosterone (10 mg/kg).
Exposed animals via nose-only inhalation to clean air or 0.8 ppm ozone for 4 hours.
Quantified circulating stress hormones, inflammatory markers in lung and plasma, and metabolic indices across the lungs, heart, liver, kidney, and spleen.
Ozone inhalation provoked a 2-fold increase in plasma corticosterone that was blocked by metyrapone, whereas plasma epinephrine levels remained unchanged.
Pharmacological inhibition of corticosterone synthesis increased lung and circulating inflammatory signaling after ozone exposure.
Metyrapone modified ozone's effects on insulin and glucagon, but not ghrelin or PAI-1, and exogenous corticosterone reproduced the multi-organ immunosuppressive and metabolic alterations.

Cite This Study

Thomson et al. (2016) studied this question.

synapsesocial.com/papers/6a8aaf68d513dfc69d721eb5 https://doi.org/10.1093/toxsci/kfw061

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Implication

Animal experiment demonstrates ozone alters inflammatory and metabolic pathways via corticosterone in rats, indicating stress hormones mediate systemic air pollutant toxicity.

Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways

Discussion

Member takes

Implication

Key Points

Cite This Study

Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways

Discussion

Member takes

Implication

Key Points

Cite This Study

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