Why the study?
Does activated protein C protect rat cortical and hippocampal neurons from glutamate excitotoxicity via the endothelial protein C receptor?
Population
Rat cortical and hippocampal neurons in culture
Comparison
Activated protein C (APC) vs Blocking EPCR antibodies or control conditions
Design
Preclinical
Authors
Loading...
Extends APC-EPCR neuroprotection data in rodents; leaves open translation to human excitotoxicity disorders.
Does activated protein C protect rat cortical and hippocampal neurons from glutamate excitotoxicity via the endothelial protein C receptor?
Activated protein C exerts neuroprotective effects against glutamate excitotoxicity in rat cortical and hippocampal neurons via the endothelial protein C receptor and protease-activated receptor-1.
Горбачева et al. (2009) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: