Why the study?
Does CO2 inhalation alter the bronchodilator effects of directly and indirectly acting sympathomimetic amines in guinea-pigs?
Population
Guinea-pigs with histamine-induced bronchospasm
Comparison
Nine sympathomimetic amines administered during… vs Administration of the same sympathomimetic…
Design
Preclinical
Authors
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May limit indirect sympathomimetic efficacy in hypercapnia; hypothesis-generating in guinea-pig model, human relevance undetermined.
Does CO2 inhalation alter the bronchodilator effects of directly and indirectly acting sympathomimetic amines in guinea-pigs?
Hypercapnia (10% CO2) selectively abolishes the bronchodilator effects of indirectly acting sympathomimetic amines while preserving the effects of directly acting ones in a guinea-pig model.
Atkinson et al. (1970) studied this question.
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