A synthetic route; to 3,4‐dihydroxyphenyl‐(2‐piperidyl)earbinols is described. These novel catecholamines may be regarded as derivatives of adrenaline containing a cyclic side‐chain moiety. Their biological action appears to be more selective than that of adrenaline or isoprenaline and the more active of these compounds show promise as powerful bronchodilators with minimum cardiac effect.
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Sankey et al. (1972) studied this question.
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