Key result
Co-expressed differentially expressed genes ZNF566, PDZK1IP1, ZFHX3, and PITX2, coupled with predicted miRNAs miR-27a-3p, miR-27b-3p, and miR-494-3p, are significantly associated with atrial fibrillation-related stroke.
Why the study?
AF is a major cause of ischemic stroke, but the molecular relationships and potential biomarkers and therapeutic targets of AF-related stroke needed to be clarified through co-expressed gene analysis.
Observational (n=105)
Bioinformatic analysis identifies ZNF566, PDZK1IP1, ZFHX3, and PITX2 genes and associated miRNAs as potential novel biomarkers for atrial fibrillation-related stroke.
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Suggests candidate AF-stroke biomarkers; hypothesis-generating and requires prospective validation before clinical use.
Zou et al. (2019) conducted an observational in Atrial fibrillation and stroke (n=105). Atrial fibrillation and stroke vs. Sinus rhythm and controls was evaluated on Differentially expressed genes (DEGs). Co-expressed differentially expressed genes ZNF566, PDZK1IP1, ZFHX3, and PITX2, coupled with predicted miRNAs miR-27a-3p, miR-27b-3p, and miR-494-3p, are significantly associated with atrial fibrillation-related stroke.
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