Key result
An elevated nocturnal heart rate above 80 bpm in newly diagnosed hypertensive patients was associated with significantly more severe target organ damage, including a higher left ventricular mass index, compared to a heart rate below 70 bpm.
Why the study?
Elevated nocturnal heart rate is linked to cardiovascular events in hypertension, but its ability to predict the occurrence and progression of target organ damage requires further investigation.
Does elevated nocturnal heart rate predict the presence and severity of target organ damage in newly diagnosed hypertensive patients?
Cross-Sectional (n=145)
No
Does elevated nocturnal heart rate predict the presence and severity of target organ damage in newly diagnosed hypertensive patients?
Answers are grounded in this paper and cite their sources.
Elevated nocturnal heart rate, particularly above 80 bpm, is associated with increased severity of target organ damage in newly diagnosed hypertensive patients.
Background: Elevated nocturnal heart rate (NHR) has been linked to an increased risk of cardiovascular events and mortality in hypertensive patients. However, the ability of NHR to predict the occurrence and progression of target organ damage (TOD) in these patients requires further investigation. This study aims to evaluate the predictive value of NHR in forecasting the presence and severity of TOD in hypertensive patients, using a combination of clinical and laboratory parameters. Methods: A total of 145 hypertensive patients were monitored for blood pressure and nocturnal heart rate. Patients were categorized into two groups based on the presence or absence of TOD and their NHR. The left ventricular mass index (LVMI), glomerular filtration rate (GFR), carotid intima media index (CTIM), and left ventricular ejection fraction (LVEF) were measured, and multiple linear regression was used to determine the predictive value of NHR on these indices. Results: The group with TOD had significantly higher NHR than the group without TOD. LVMI, GFR, CTIM, and LVEF varied significantly among the three subgroups, with the NHR3 group showing marked differences compared to the NHR2 and NHR1 groups (p < 0.01 or p < 0.05). Excessively rapid NHR had diverse impacts on all categories of target organs, particularly on LVMI and CTIM. Conclusion: Augmentation of nocturnal heart rate causes heightened harm to the target organs, with the most significant impact observed in LVMI and CTIM. No significant difference in the severity of TOD was observed between patients with an NHR of less than 70 bpm and those with an NHR between 70 and 80 bpm. However, an NHR above 80 bpm resulted in more severe TOD. These findings suggest that monitoring NHR in hypertensive patients may help prevent and manage TOD.
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Li et al. (2023) conducted a cross-sectional in Hypertension (n=145). Elevated nocturnal heart rate (>80 bpm) vs. Normal nocturnal heart rate (<70 bpm) was evaluated on Left ventricular mass index (LVMI, g/m2) (p=<0.05). An elevated nocturnal heart rate above 80 bpm in newly diagnosed hypertensive patients was associated with significantly more severe target organ damage, including a higher left ventricular mass index, compared to a heart rate below 70 bpm.
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