Key result
Post-MI depression was associated with an increased risk of all-cause mortality (OR 2.25; 95% CI 1.73-2.93; P<.001), cardiac mortality, and cardiac events.
Why the study?
Does post-MI depression increase the risk of mortality and cardiac events in patients following myocardial infarction?
Population
16,889 MI patients from 29 studies (41 comparisons)
Comparison
Post-MI depression vs No post-MI depression
Design
Meta-analysis
Follow-up
average 16 months (up to 24 months)
Authors
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Highlights prognostic value of post-MI depression screening; leaves open whether treatment improves survival.
Meta-Analysis (n=16,889)
Does post-MI depression increase the risk of mortality and cardiac events in patients following myocardial infarction?
Odds Ratio: 2.25 (95% CI 1.73–2.93)
p-value: p=<.001
Post-MI depression is associated with a 1.6- to 2.7-fold increased risk of mortality and cardiac events within 24 months, emphasizing the prognostic importance of depression after myocardial infarction.
Meijer et al. (2011) conducted a meta-analysis in Post-myocardial infarction depression (n=16,889). Post-MI depression vs. No post-MI depression was evaluated on All-cause mortality (OR 2.25, 95% CI 1.73-2.93, p=<.001). Post-MI depression was associated with an increased risk of all-cause mortality (OR 2.25; 95% CI 1.73-2.93; P<.001), cardiac mortality, and cardiac events.
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