Key result
The positivity rate of Enterovirus significantly decreased from 8.9% before the COVID-19 pandemic to 3.3% during the pandemic and 4.0% after the pandemic.
Why the study?
Enteroviruses encompass a large group of genotypes causing varied and sometimes serious pathologies, prompting analysis of EV diagnosis and classification patterns over a 10-year period.
Observational (n=166,674)
No
Absolute Event Rate: 3.3% vs 8.9%
p-value: p=<0.0001
Enterovirus positivity rates were high but significantly decreased during the COVID-19 pandemic, with distinct species predominating in different age groups and clinical syndromes.
EV detection rates fell during the pandemic; leaves open whether mitigation measures or testing changes altered circulation patterns.
Enteroviruses (EVs) are a large group of genotypes that cause a variety of pathologies, some of them very serious. This study analyzed the last 10 years (2014-2023) of EVs diagnosis and classification. In 166,674 samples collected, EVs were found in 9,535 (5.7%) by rt-RT-PCR, and 332 (3.5%) were classified by Sanger methods. Symptoms were analyzed in 7623 cases. EVs were found in 5718/63,829 (8.9%) before, 1384/42,373 (3.3%) during and 2433/60,472 (4%) after the Covid pandemic (p < 0.0001), and in 7249/69,700 (10.4%) children under 6 years and in 2286/96,974 (2.35%) in oldest (p < 0.0001). The positive rate of EVs was high but decreased during the Covid period. In the youngest children EVs-A (associated with exantematohous disorders as well as respiratory manifestations and febrile syndromes) was most common, while EVs-B (frequent in neurological symptoms) was most common in children aged 6-15 years and EVs-D (associated to respiratory manifestations) in adults.
No takes yet. Share an insight, caveat, or question.
Rojo‐Alba et al. (2024) conducted an observational in Enterovirus infection (n=166,674). SARS-CoV-2 pandemic vs. Pre-pandemic period was evaluated on Enterovirus positivity rate (p=<0.0001). The positivity rate of Enterovirus significantly decreased from 8.9% before the COVID-19 pandemic to 3.3% during the pandemic and 4.0% after the pandemic.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: