Key result
Among 1,845 parechovirus-positive samples in Europe, Parechovirus A3 was the most common type (n=278) and correlated with severe disease in neonates.
Why the study?
Parechovirus infections typically affect neonates and young children with manifestations ranging from asymptomatic to life-threatening, prompting an assessment of European laboratory capacity, circulation, seasonality, and epidemiology.
Observational (n=1,845)
Yes
There is wide capacity in Europe to detect and type parechovirus, with type A3 being the most common and associated with severe disease in neonates.
Variable European lab capacity for parechovirus detection; leaves open needs for standardized surveillance and prospective epidemiology studies.
Parechovirus infections usually affect neonates and young children; manifestations vary from asymptomatic to life-threatening. We describe laboratory capacity in Europe for assessing parechovirus circulation, seasonality, and epidemiology. We used retrospective anonymized data collected from parechovirus infection case-patients identified in Europe during January 2015-December 2021. Of 21 laboratories from 18 countries that participated in the study, 16 (76%) laboratories with parechovirus detection capacity reported 1,845 positive samples; 12/16 (75%) with typing capability successfully identified 517 samples. Parechovirus A3 was the most common type (n = 278), followed by A1 (153), A6 (50), A4 (13), A5 (22), and A14 (1). Clinical data from 1,269 participants highlighted correlation of types A3, A4, and A5 with severe disease in neonates. We observed a wide capacity in Europe to detect, type, and analyze parechovirus data. To enhance surveillance and response for PeV outbreaks, sharing typing protocols and data on parechovirus-positive cases should be encouraged.
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Bubba et al. (2024) conducted an observational in Parechovirus infection (n=1,845). Parechovirus infection was evaluated on Parechovirus types and clinical correlation. Among 1,845 parechovirus-positive samples in Europe, Parechovirus A3 was the most common type (n=278) and correlated with severe disease in neonates.
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