What question did this study set out to answer?

To determine the in vivo roles of pulmonary collectins SP-A and SP-D in restricting influenza A virus infection and modulating host inflammatory responses across distinct viral strains.

July 27, 2004Journal of VirologyOpen Access

Pulmonary Collectins Modulate Strain-Specific Influenza A Virus Infection and Host Responses

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Authors

SHSamuel HawgoodUniversity of California, San Francisco CBCynthia L. BrownTexas Tech University JEJess EdmondsonUniversity of California, San Francisco

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Implication

Gene-targeted mouse study demonstrates that pulmonary surfactant protein D curbs influenza A replication and inflammation via specific viral glycosylation, highlighting critical innate immune...

Key Points

To determine the in vivo roles of pulmonary collectins SP-A and SP-D in restricting influenza A virus infection and modulating host inflammatory responses across distinct viral strains.
Challenged SP-A-deficient, SP-D-deficient, double-knockout, and wild-type C57BL/6 mice with influenza A virus strains that either possessed or lacked glycosylation at the N165 site of the HA1 hemagglutinin domain.
Quantified viral replication kinetics, animal weight loss, pulmonary neutrophil recruitment, and local cytokine release following viral challenge.
SP-D significantly restricted viral replication and reduced weight loss, neutrophil influx into the lung, and local cytokine production only when the infecting influenza A virus possessed N165 glycosylation on the HA1 domain.
SP-A deficiency yielded no significant alteration in lung viral titers for either strain except for a transient variance at day 2 post-infection, and double-knockout mice displayed phenotype severity equivalent to SP-D-deficient mice.

Cite This Study

Hawgood et al. (2004) studied this question.

synapsesocial.com/papers/6a8ac3adfe910689a28925a9 https://doi.org/10.1128/jvi.78.16.8565-8572.2004

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Implication

Gene-targeted mouse study demonstrates that pulmonary surfactant protein D curbs influenza A replication and inflammation via specific viral glycosylation, highlighting critical innate immune...

Pulmonary Collectins Modulate Strain-Specific Influenza A Virus Infection and Host Responses

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Cite This Study

Pulmonary Collectins Modulate Strain-Specific Influenza A Virus Infection and Host Responses

Discussion

Member takes

Implication

Key Points

Cite This Study

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