Key result
Exogenous calcium and the calcium ionophore A23187 significantly increased microsomal triglyceride transfer protein (MTP) activity in rat hepatocytes, suggesting that hepatocellular calcium contributes to MTP activation.
Why the study?
Does hepatocellular Ca2+ modulate microsomal triglyceride transfer protein (MTP) activity and triglyceride release in rat hepatocytes?
Does hepatocellular Ca2+ modulate microsomal triglyceride transfer protein (MTP) activity and triglyceride release in rat hepatocytes?
Absolute Event Rate: 3639% vs 2649%
p-value: p=<0.05
Hepatocellular calcium contributes to MTP activation and subsequent triglyceride release, suggesting that suppressing hepatocellular Ca2+ may inhibit hypertriglyceridemia.
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Hepatocellular calcium may modulate MTP activity and triglyceride release; hypothesis-generating in rats and requires human validation.
Cho et al. (2005) studied Hypertriglyceridemia (in vitro model). Calcium (CaCl2) and A23187 vs. Control (physiological culture medium) was evaluated on Microsomal triglyceride transfer protein (MTP) activity (p=<0.05). Exogenous calcium and the calcium ionophore A23187 significantly increased microsomal triglyceride transfer protein (MTP) activity in rat hepatocytes, suggesting that hepatocellular calcium contributes to MTP activation.
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