What does this research mean for the field?

Microsomal triglyceride transfer protein (MTP) is the only tissue-specific component, other than apolipoprotein B (apoB), required for the secretion of apoB-containing lipoproteins, a process regulated by the competition between lipoprotein assembly and intracellular degradation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1994Journal of Biological ChemistryOpen Access

Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells.

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Population

COS-1 cells expressing carboxyl-terminal truncated forms of apoB (apoB17 and apoB41)

Comparison

Cotransfection with microsomal triglyceride… vs Expression of apoB41 without MTP; untreated cells

Design

Preclinical

Authors

JLJames LeiperUniversity of Glasgow JBJ.D. BaylissGuy's Hospital RPRichard J. PeaseUniversity of Leeds

Discussion

Member takes

Implication

MTP-apoB findings in heterologous cells warrant no clinical lipid changes; extends genetic links to ABL but leaves open human validation.

Structured PICO

Population

COS-1 cells expressing carboxyl-terminal truncated forms of apoB (apoB17 and apoB41)

Intervention

Cotransfection with microsomal triglyceride transfer protein (MTP); treatment with N-Acetyl-leucyl-leucyl-norleucinal (ALLN) or oleate

Comparator

Expression of apoB41 without MTP; untreated cells

Outcome

Secretion of apoB41 as a buoyant lipoprotein particlesurrogate

MTP is necessary and sufficient to mediate the secretion of apoB-containing lipoproteins from heterologous cells, with secretion determined by competitive processes of assembly and degradation.

Cite This Study

Leiper et al. (1994) studied this question.

synapsesocial.com/papers/6a1d705f73c56dd1bd2fae1c https://doi.org/10.1016/s0021-9258(17)31740-4

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Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider