Why the study?
Is microsomal triglyceride transfer protein (MTP) absent in individuals with abetalipoproteinemia compared to controls?
Population
4 subjects with abetalipoproteinemia and 8 control individuals
Comparison
Assessment of MTP activity and the 88-kilodalton… vs Control individuals
Design
Case-control
Authors
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MTP absence in abetalipoproteinemia supports its role in lipoprotein assembly; leaves open causality and clinical translation pending larger studies.
Is microsomal triglyceride transfer protein (MTP) absent in individuals with abetalipoproteinemia compared to controls?
The absence of MTP in abetalipoproteinemic subjects suggests that a defect in MTP is the molecular basis for the disease and is required for lipoprotein assembly.
Wetterau et al. (1992) studied this question.
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