Novel Asymmetric Synthesis of an Indolizidine Alkaloid, (+)-Lentiginosine Employing Highly Stereoselective Hydrogenation of α-Hydroxypyrrolidine

All articles of this category An efficient and novel process is described for the asymmetric synthesis of a ( 1S , 2S , 8aS )-dihydroxyindolizidine alkaloid, (+)-lentiginosine in which the asymmetric deoxygenation of the quaternary α-hydroxypyrrolidine derivative derived from D-xylose is used as a key step. indolizidine alkaloid - (+)-lentiginosine - deoxygenation - α-hydroxypyrrolidine - xylose