What question did this study set out to answer?

To review digestive hormone physiology and evaluate the neuroendocrine mechanisms underpinning surgical, endoscopic, and pharmacologic weight-loss interventions.

August 9, 2026Endocrine Reviews

Digestive hormones and their impact on bariatric and pharmacologic weight-loss therapies

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Authors

MAMaxime AmoyelInserm CCClaire CaretteInserm TPTigran PoghosyanUniversité Claude Bernard Lyon 1

Discussion

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Implication

Review reveals distinct digestive hormone adaptations across surgical, endoscopic, and pharmacologic therapies in obesity, highlighting shared gut-brain pathways in metabolic regulation.

Key Points

To review digestive hormone physiology and evaluate the neuroendocrine mechanisms underpinning surgical, endoscopic, and pharmacologic weight-loss interventions.
Synthesized evidence on digestive hormone physiology, focusing on hunger, satiation, and satiety regulation via gut-brain and hypothalamic signaling.
Compared neuroendocrine alterations across bariatric surgeries (sleeve gastrectomy, Roux-en-Y gastric bypass), endoscopic techniques (endoscopic sleeve gastroplasty, intragastric balloons), and incretin-based pharmacotherapies.
Bariatric surgical procedures achieve profound and persistent hormonal remodeling, while endoscopic sleeve gastroplasty provides more modest endocrine shifts and intragastric balloons offer transient delays in gastric emptying with limited durability.
Incretin-based therapies, including GLP-1 receptor agonists and novel multi-receptor agonists, replicate key post-bariatric hormonal adaptations to achieve clinically meaningful weight reduction.

Cite This Study

Amoyel et al. (2026) studied this question.

synapsesocial.com/papers/6a8ac7f3f71b672e3df44641 https://doi.org/10.1210/endrev/bnag032

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Implication

Review reveals distinct digestive hormone adaptations across surgical, endoscopic, and pharmacologic therapies in obesity, highlighting shared gut-brain pathways in metabolic regulation.

Digestive hormones and their impact on bariatric and pharmacologic weight-loss therapies

Discussion

Member takes

Implication

Key Points

Cite This Study

Digestive hormones and their impact on bariatric and pharmacologic weight-loss therapies

Discussion

Member takes

Implication

Key Points

Cite This Study

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