Key result
Normoxic heliox increased quadriceps muscle blood flow compared with air during near-maximal exercise (35.8 vs 29.0 ml·min(-1)·100 g(-1); P<0.05), without evidence of blood flow redistribution.
Why the study?
Does normoxic heliox breathing improve locomotor muscle oxygen delivery via blood flow redistribution from intercostal muscles during exercise in COPD patients?
Population
10 patients with chronic obstructive pulmonary disease (FEV = 50.5 ± 5.5% predicted) who did not exhibit…
Comparison
Normoxic heliox breathing during exercise tests… vs Air breathing during exercise tests at 75% and…
Design
Other
Authors
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Challenges redistribution hypothesis for heliox benefit in COPD exercise; leaves mechanism open and should not change practice.
Does normoxic heliox breathing improve locomotor muscle oxygen delivery via blood flow redistribution from intercostal muscles during exercise in COPD patients?
Absolute Event Rate: 35.8% vs 29%
p-value: p=<0.05
Normoxic heliox breathing increases both locomotor and respiratory muscle blood flow during near-maximal exercise in COPD patients, indicating that blood flow redistribution from respiratory to locomotor muscles is not the mechanism for improved oxygen delivery.
Vogiatzis et al. (2011) studied Chronic obstructive pulmonary disease (COPD) (n=10). Normoxic heliox vs. Air was evaluated on Quadriceps muscle blood flow during near-maximal exercise (ml·min(-1)·100 g(-1)) (p=<0.05). Normoxic heliox increased quadriceps muscle blood flow compared with air during near-maximal exercise (35.8 vs 29.0 ml·min(-1)·100 g(-1); P<0.05), without evidence of blood flow redistribution.
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