Diabetes Refractory to Insulin, With Report of a Case

Case Reports1 May 1936DIABETES REFRACTORY TO INSULIN, WITH REPORT OF A CASESAMUEL S. ALTSHULER, M.D., F.A.C.P., S. E. GOULD, M.D.SAMUEL S. ALTSHULER, M.D., F.A.C.P.Search for more papers by this author, S. E. GOULD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-11-1595 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn reviewing the literature on this subject one is struck by the fact that many cases are spoken of as "insulin refractory" which might better be termed "insulin resistant," that is, cases in which an unusually large amount of insulin must be administered in order to control the glycosuria. The case which we are reporting is truly insulin refractory; no relationship is demonstrable between the amounts of insulin given and the subsequent glycosuria.In most instances the physiological responses to insulin are predictable, but the mechanism of its action is still problematical. The proper understanding of this mechanism is reserved...Bibliography1. VON MERINGMINKOWSKI : Arch. f. exper. Path. u. Pharmakol., 1889, xxvi, 371. Google Scholar2. BANTINGBEST FGCH: Internal secretion of pancreas, Jr. Lab. and Clin. Med., 1922, vii, 251-266. Google Scholar3. HOUSSAYLEWIS ABJT: Suprarenals and pancreatic diabetes, Rev. Asoc. méd. argent., 1921, xxxiv, 1099-1103. Google Scholar4. COLWELL AR: Relation of hypophysis to diabetes mellitus, Medicine, 1927, vi, 1-39. CrossrefGoogle Scholar5. COLLIP JB: Diabetogenic, thyrotropic, adrenetropic and parathyrotropic factors of the pituitary, Jr. Am. Med. Assoc., 1935, civ, 827. CrossrefGoogle Scholar6. POLLACK H: Insulin resistance, Proc. Staff. Meet. Mayo Clinic, 1933, viii, 453. Google Scholar7. MAHLERPASTERNY PK: Klinische Beobachtungen über Insulin Wirkung beim Diabetes mellitus, Med. Klin., 1924, xx, 337. Google Scholar8. ULRICH H: Antagonism between insulin and pituitary extract, Arch. Int. Med., 1928, xli, 855. Google Scholar9. CHARLTON FH: Diabetes refractory to insulin relieved by antiluetic treatment, Endocrinology, 1924, viii, 235. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Eloise, Michigan*Received for publication August 26, 1935.From the Departments of Medicine and Pathology of the William J. Seymour Hospital, Eloise, Michigan, and the Department of Pathology of Wayne University, College of Medicine, Detroit. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPituitary apoplexy: its incidence and clinical significanceDie Behandlung der sackförmigen intrakraniellen AneurysmenAcute Hemorrhage into Pituitary Adenomas 1 May 1936Volume 9, Issue 11Page: 1595-1603KeywordsHospital medicineInsulin ePublished: 1 December 2008 Issue Published: 1 May 1936 PDF downloadLoading ...