The relationship between biochemical parameters, interleukin-6 and ovarian morphology in polycystic ovary syndrome

Objectives: The aim of this study is to investigate relationships between biochemical parameters and interleukin-6 according to the ovarian morphology in polycystic ovary syndrome (PCOS). Materials and methods: A total of 85 patients with PCOS were divided into three groups according to the ultrasonographic examination of the ovaries; group 1 (with no polycystic image at any of the ovaries, n=22), group 2 (with polycystic image at only one ovary, n=41), and group 3 (with polycystic image at both of the ovaries, n=22). Serum interleukin 6 (IL-6), hormone levels, and homeostasis model assessment-insulin resistance (HOMA-IR) were measured. Results: The mean serum IL-6 levels for groups 1, 2 and 3 were 14.65 ± 6.18 pg/mL, 16.22 ± 6.55 pg/mL, and 14:53 ± 7.32 pg/mL, respectively. There was no statically difference between three groups for serum IL-6 levels (p>0.05). For metabolic profile, the mean of HOMA-IR was 3.09±1.56 for group 2 and this was significantly lower than other groups (p<0.05). Conclusions: There were no differences in hormonal and inflammatory markers according to the ovarian morphology in PCOS patients based on data derived from our study.