Key result
Aortic pulse wave velocity and carotid pulse pressure were positively correlated with free tissue factor pathway inhibitor levels in healthy postmenopausal women.
Why the study?
The relationship between aortic stiffness or pulse pressure and procoagulant or anticoagulant factors in women older than 60 was unclear, as was the effect of pulsatile stretch on these factors in vascular smooth muscle cells.
Is aortic stiffness or pulse pressure associated with free TFPI levels in postmenopausal women, and does pulsatile stretch influence TFPI synthesis in VSMCs?
Cross-Sectional (n=123)
Is aortic stiffness or pulse pressure associated with free TFPI levels in postmenopausal women, and does pulsatile stretch influence TFPI synthesis in VSMCs?
Answers are grounded in this paper and cite their sources.
Free TFPI increases as vascular wall function deteriorates and pulse pressure increases in postmenopausal women, supported by in vitro evidence that pulsatile stretch enhances TFPI synthesis in VSMCs.
Objective— To investigate in women older than 60 whether aortic stiffness or pulse pressure (PP) is associated with selected procoagulant or anticoagulant factors and to examine whether pulsatile stretch influences these factors in human vascular smooth muscle cells (VSMCs) in vitro. Methods and Results— Aortic pulse wave velocity (PWV) and carotid PP were studied in 123 apparently healthy postmenopausal women. PWV, PP, von Willebrand factor, and free tissue factor pathway inhibitor (TFPI), but not mean arterial pressure, increased with age. Free TFPI and PWV were positively correlated, even after adjustment for age and PP and other confounding parameters. In vitro, 5% or 10% pulsatile stretch (at 1 Hz) enhanced TFPI synthesis and secretion by VSMCs in a time-independent manner (1 to 48 hours) without changes in protein level of smooth muscle myosin heavy chain. Application of 5% static stretch had no effect. Conclusion— In postmenopausal women, free TFPI increases as vascular wall function deteriorates and PP increases. These findings are supported by the increase in TFPI synthesized by VSMCs in response to cyclic stress in vitro. They suggest that VSMCs require pulsatility to interfere with the coagulation process and highlight the relevance of plasma free TFPI levels to cardiovascular diseases.
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Regnault et al. (2011) conducted a cross-sectional in Healthy postmenopausal women (n=123). Aortic pulse wave velocity and carotid pulse pressure was evaluated on Correlation between free tissue factor pathway inhibitor (TFPI) and aortic pulse wave velocity/pulse pressure. Aortic pulse wave velocity and carotid pulse pressure were positively correlated with free tissue factor pathway inhibitor levels in healthy postmenopausal women.
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