Key result
MDCT lesion density was significantly lower in culprit lesions compared to non-culprit lesions (33.2 vs 76.4 HU, p<0.001), and a cutoff of 49.6 HU discriminated culprit lesions with 87.9% accuracy.
Why the study?
Does 64-slice MDCT accurately identify culprit lesions and active complex lesions in patients with early non-ST-elevation acute myocardial infarction?
Observational (n=103)
Double-blind (MDCT and CCAG reviewers blinded to clinical data)
No
Does 64-slice MDCT accurately identify culprit lesions and active complex lesions in patients with early non-ST-elevation acute myocardial infarction?
Absolute Event Rate: 33.2% vs 76.4%
p-value: p=<0.001
In patients with early non-ST-elevation AMI, 64-slice MDCT can non-invasively identify culprit and active complex lesions based on plaque density and morphology.
No takes yet. Share an insight, caveat, or question.
May aid non-invasive culprit lesion detection in early NSTE-AMI; leaves open prospective validation before clinical use.
Huang et al. (2008) conducted an observational in First non-ST elevation acute myocardial infarction (n=103). Culprit lesions vs. Non-culprit lesions was evaluated on MDCT lesion density (HU) (p=<0.001). MDCT lesion density was significantly lower in culprit lesions compared to non-culprit lesions (33.2 vs 76.4 HU, p<0.001), and a cutoff of 49.6 HU discriminated culprit lesions with 87.9% accuracy.
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