Key result
Plasma resistin concentration is independently associated with increased vascular stiffness in patients with arterial hypertension (OR 1.46).
Why the study?
The study was conducted to investigate the association of plasma resistin concentration with the CAVI vascular stiffness index and identify factors associated with increased vascular stiffness in arterial hypertension.
Is plasma resistin concentration associated with increased vascular stiffness in patients with arterial hypertension?
Cross-Sectional (n=72)
No
Is plasma resistin concentration associated with increased vascular stiffness in patients with arterial hypertension?
Plasma resistin concentration >4.95 ng/ml is an independent marker of increased vascular stiffness in patients with arterial hypertension, suggesting its potential utility in cardiovascular risk assessment.
Answers are grounded in this paper and cite their sources.
May link resistin to vascular stiffness in hypertension; leaves open its value as biomarker or target.
The aim of the study: to investigate the association of plasma resistin concentration with the vascular stiffness index CAVI and to identify factors associated with increased vascular stiffness in patients with arterial hypertension (AH). Materials and methods. 72 patients (34 men and 38 women) with AH aged 48 to 84 years were included in the study. Type 2 diabetes mellitus (T2DM) was diagnosed in 16 (22.2%) patients. Together with the standard investigations, all patients underwent determination of plasma resistin concentration and measurement of vascular stiffness based on the CAVI index. Results. All patients with AH were divided into 2 groups: patients with increased vascular stiffness (CAVI≥9) – 32 people (group 1) and patients with normal vascular stiffness (CAVI<9) – 40 people (group 2). A significantly higher concentration of resistin in blood plasma was observed in patients of group 1 – 6.23 [4.99; 8.35] ng/ml compared to group 2 – 4.1 [3.8; 5.58] ng/ml, p=0.036. Univariate linear regression analysis revealed a direct relationship between plasma resistin concentration and CAVI index (beta1=0.34; SD=0.08; p<0.001). According to multivariate regression analysis, independent markers of increased vascular stiffness in patients with AH were: age (OR=1.19, CI=1.06-1.30), T2DM (OR=2.39, CI=1.16-5.99), plasma resistin concentration (OR=1.46, CI=1.09-2.27), p<0.05. Resistin level more than 4.95 ng/ml with sensitivity of 65.2% and specificity of 56.5% allows to diagnose increased arterial stiffness in patients with AH (AUC=0.673, p<0.05). Conclusion. Independent markers of vascular stiffness in patients with AH are not only age and T2DM, but also a plasma resistin concentration of more than 4.95 ng/ml.
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Pokrovskaya et al. (2025) conducted a cross-sectional in Arterial hypertension (n=72). Plasma resistin concentration vs. Normal vascular stiffness (CAVI < 9) was evaluated on Increased vascular stiffness (CAVI ≥ 9) (OR 1.46, 95% CI 1.09-2.27, p=<0.05). Plasma resistin concentration is independently associated with increased vascular stiffness in patients with arterial hypertension (OR 1.46).
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