What is the clinical evidence from this study?

Study design: Other. Population: Healthy (animal model) (n=25). Intervention: Phentolamine and Atenolol vs. Baseline (pre-infusion). Primary outcome: Changes in stiffness of the aorta (aBeta) and iliofemoral artery (ifBeta).

September 10, 2020Journal of Atherosclerosis and ThrombosisOpen Access

Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits

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Key result

Phentolamine decreased iliofemoral artery stiffness (ifBeta) but increased aortic stiffness (aBeta), whereas atenolol decreased blood pressure without changing the stiffness of either artery.

Why the study?

Does administration of phentolamine or atenolol alter arterial stiffness of the aorta and iliofemoral artery in rabbits?

Population

Rabbits

Comparison

Administration of phentolamine vs atenolol

Authors

SKShin-ichiro KatsudaFukushima Medical University YFYuko Fujikura YHYuko HorikoshiFukushima Medical University

Discussion

Member takes

Implication

These regional stiffness differences should not yet inform therapy choices; hypothesis-generating for artery-specific drug responses.

Structured PICO

Does administration of phentolamine or atenolol alter arterial stiffness of the aorta and iliofemoral artery in rabbits?

Population

25 anesthetized male Japanese white rabbits aged 10-12 months were studied to evaluate arterial stiffness responses to phentolamine and atenolol.

Intervention

Phentolamine (50 µg/kg/min) and atenolol (10 mg/kg/min) infused intravenously for 2 minutes.

Comparator

Baseline (before infusion).

Outcome

Changes in stiffness of the aorta (aBeta) and iliofemoral artery (ifBeta) in response to reduced blood pressure.surrogate

The stiffness of the aorta and iliofemoral artery is regulated separately during decreased blood pressure induced by the alpha-blocker phentolamine, but not by the beta-blocker atenolol.

Limitations

This study was performed on rabbits under anesthesia; thus, the observation time was relatively short.
The results were not easily translated into humans after long term phentolamine and atenolol administration.

Cite This Study

Katsuda et al. (2020) studied Healthy (animal model) (n=25). Phentolamine and Atenolol vs. Baseline (pre-infusion) was evaluated on Changes in stiffness of the aorta (aBeta) and iliofemoral artery (ifBeta). Phentolamine decreased iliofemoral artery stiffness (ifBeta) but increased aortic stiffness (aBeta), whereas atenolol decreased blood pressure without changing the stiffness of either artery.

synapsesocial.com/papers/6a8acafca42d46e0ffca9776 https://doi.org/10.5551/jat.57364

Topics

Hypertension management

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Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider