Why the study?
Does pacemaker treatment improve survival and reduce sudden death in patients with high-grade atrioventricular block compared to conservative treatment?
Does pacemaker treatment improve survival and reduce sudden death in patients with high-grade atrioventricular block compared to conservative treatment?
Pacemaker implantation in patients with high-grade AV block is associated with improved long-term survival and a reduction in sudden death compared to conservative management.
Answers are grounded in this paper and cite their sources.
May support pacemakers in high-grade AV block; hypothesis-generating and requires randomized confirmation.
One-hundred and eighty-one patients with chronic and with intermittent high-grade atrioventricular block (AVB) were studied retrospectively. Seventy-one were treated with fixed-rate, 51 with demand-type pacemaker, 59 were treated conservatively. Observation time was three years minimum and 14.5 years maximum. The mean age was about seven years higher, and 8.7% more patients had chronic AVB in the conservatively treated than in the pacemaker-treated group. About 12% more patients had Adams-Stokes attacks in the pacemaker group than in the conservatively treated group. There were 7% more patients with coronary heart disease (CHD) in the pacemaker group, and 10% more with aortic valve disease among the conservatively treated. Totally 4.4% of the patients had a calcification of the mitral annulus fibrosus. The two groups were comparable as regards functional class (NYHA) and heart size. Survival showed 31% more sudden deaths in the conservatively treated than in the pacemaker group. Sudden deaths were not more frequent among the patients with CHD than in those without. Long-term survival showed the more favourable result for the patients with than without pacemaker treatment. There were eight (11.3%) unexplained sudden deaths among the patients treated with fixed-rate pacemaker, only three (5.9%) among those treated with a demand unit. The fixed-rate and the demand units showed a mean longevity of 37.2 and 34.6 months, respectively.
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Ohm et al. (1978) studied this question.
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