Key result
Biological valves were associated with a higher risk of all-cause mortality compared to mechanical valves in patients with infective endocarditis (HR 1.22; 95% CI 1.03-1.44; P=0.023).
Why the study?
Does biological valve replacement compared to mechanical valve replacement improve prognosis in patients with infective endocarditis?
Population
11 publications pooling 10,754 patients with infective endocarditis
Comparison
Biological valve replacement vs Mechanical valve replacement
Design
Meta-analysis
Authors
Loading...
Favors mechanical valves for infective endocarditis survival, but confounding by baseline characteristics limits clinical application.
Meta-Analysis (n=10,754)
Yes
Does biological valve replacement compared to mechanical valve replacement improve prognosis in patients with infective endocarditis?
Hazard Ratio: 1.22 (95% CI 1.03–1.44)
p-value: p=0.023
Mechanical valves are associated with better unadjusted survival and lower reoperation rates than biological valves in infective endocarditis, though this difference may be driven by baseline patient characteristics.
Tao et al. (2017) conducted a meta-analysis in Infective endocarditis (n=10,754). Biological valves vs. Mechanical valves was evaluated on All-cause mortality (HR 1.22, 95% CI 1.03 to 1.44, p=0.023). Biological valves were associated with a higher risk of all-cause mortality compared to mechanical valves in patients with infective endocarditis (HR 1.22; 95% CI 1.03-1.44; P=0.023).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: