Key result
Elevated serum lipoprotein (a) concentration (≥20 mg/dL) was associated with a significantly higher probability of ischemic heart disease events in patients without a history of IHD (P<0.001).
Why the study?
Does elevated serum Lp(a) concentration increase the risk of ischemic heart disease and cerebral infarction in elderly patients with type-2 diabetes?
Population
158 elderly patients with type-2 diabetes, stratified by past history of cerebral infarction or ischemic…
Comparison
Elevated serum Lp(a) concentration (≥ 20 mg/dL) vs Normal serum Lp(a) concentration (< 20 mg/dL)
Design
Cohort
Follow-up
4 years
Authors
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May aid risk stratification in elderly T2D without prior IHD; leaves open whether Lp(a) lowering reduces events.
Cohort (n=158)
Does elevated serum Lp(a) concentration increase the risk of ischemic heart disease and cerebral infarction in elderly patients with type-2 diabetes?
p-value: p=<0.001
Elevated serum Lp(a) concentration is an independent risk factor for ischemic heart disease, but not for perforating artery occlusion-type cerebral infarction, in elderly patients with type-2 diabetes.
Suzuki et al. (2003) conducted a cohort in Type-2 diabetes (n=158). Elevated serum lipoprotein (a) concentration (≥ 20 mg/dL) vs. Normal serum lipoprotein (a) concentration (< 20 mg/dL) was evaluated on Incidence of ischemic heart disease (IHD) and perforating artery occlusion-type cerebral infarction (CI) (p=<0.001). Elevated serum lipoprotein (a) concentration (≥20 mg/dL) was associated with a significantly higher probability of ischemic heart disease events in patients without a history of IHD (P<0.001).
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