Key result
A 34-year-old female with unresectable epithelioid sarcoma of the parapharyngeal space achieved a complete response and remained disease-free for 40 months following chemoradiotherapy.
Why the study?
Epithelioid sarcoma is a rare soft tissue sarcoma variant with poor overall survival, and its occurrence in the parapharyngeal space is exceedingly uncommon.
Case Report (n=1)
No
Concurrent chemo-radiotherapy may be an effective and viable radical treatment option for unresectable epithelioid sarcoma of the parapharyngeal space.
May support chemoradiotherapy for unresectable epithelioid sarcoma; leaves open need for prospective validation in rare tumors.
Epithelioid sarcoma (ES) was first described by Enzinger in 1970. It is a rare variant of soft tissue sarcoma with a 5-year overall survival (OS) rate of 50%. Here, we reported a case of epithelioid sarcoma in the parapharyngeal space of an adult, resulting in a favorable prognosis after chemotherapy and radiation therapy. A 34-year-old female who complained of pharynx pain and discomfort was suspected of having a tumor in the right parapharyngeal space by CT scan. Excision biopsy suggested epithelioid sarcoma. Clinical and radiological studies did not reveal tumor distant metastasis in the patient. After excisional biopsy, the patient underwent chemotherapy and external beam radiation treatment. She has remained alive for 2 years and 7 months without recurrence since her last treatment. In this paper, we also provide a detailed review of the role of radiotherapy in the treatment of epithelioid sarcoma in previously reported cases.
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Li et al. (2021) conducted a case report in Epithelioid sarcoma of the parapharyngeal space (n=1). Chemotherapy and radiation therapy was evaluated on Tumor response and recurrence. A 34-year-old female with unresectable epithelioid sarcoma of the parapharyngeal space achieved a complete response and remained disease-free for 40 months following chemoradiotherapy.
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