Key result
Proximal-type epithelioid sarcoma in the pelvic soft tissues presented as an aggressive tumor with lymph-node metastases, leading to death 5 months after diagnosis in a 46-year-old man.
Case Report (n=1)
Highlights the importance of including proximal-type epithelioid sarcoma in the differential diagnosis of pelvic tumors.
Alerts clinicians to include proximal-type epithelioid sarcoma in pelvic tumor differentials; leaves open need for larger series on prognosis.
A case of proximal-type epithelioid sarcoma arising in the pelvic soft tissues of a 46-year-old man is presented. The tumor showed a predominantly epithelioid component with rhabdoid features, cord-like arrangement, small nests, abundant eosinophilic cytoplasm containing intracytoplasmic, paranuclear, hyaline-like globules, large vesicular nuclei, and prominent nucleoli. There were foci with alveolar arrangement and a spindle-cell proliferation. The tumor cells were positive for cytokeratin CAM5.2, vimentin, epithelial membrane antigen, and CD34. Flow cytometry showed a diploid DNA content with high S-phase fraction. The patient had pelvic lymph-node metastases. He died of the disease 5 months after diagnosis. It is important to include proximal-type epithelioid sarcoma in the differential diagnosis of pelvic tumors.
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Fukunaga et al. (1999) conducted a case report in Proximal-type epithelioid sarcoma in the pelvic soft tissues (n=1). Proximal-type epithelioid sarcoma in the pelvic soft tissues presented as an aggressive tumor with lymph-node metastases, leading to death 5 months after diagnosis in a 46-year-old man.
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