December 21, 1999Proceedings of the National Academy of SciencesOpen Access

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

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Population

Embryonic stem cell-derived cardiac myocytes as an in vitro model of postischemic reperfusion injury of…

Comparison

Targeted disruption of the MEKK1 gene and… vs Wild-type ESCM exposed to hydrogen peroxide

Design

Preclinical

Authors

TMTetsuo MinaminoGeneral / Preventive / Lipids TYToshiaki YujiriYamaguchi University PPPhilip J. PapstMBio Diagnostics (United States)

Discussion

Member takes

Implication

Hypothesis-generating in murine myocytes; leaves open MEKK1 targeting in human oxidative cardiac injury.

Structured PICO

Population

Embryonic stem cell-derived cardiac myocytes (ESCM) as an in vitro model of postischemic reperfusion injury of myocardium

Intervention

Targeted disruption of the MEKK1 gene (MEKK1-/-) and exposure to hydrogen peroxide (oxidative stress)

Comparator

Wild-type ESCM exposed to hydrogen peroxide

Outcome

Hydrogen peroxide-induced apoptosissurrogate

MEKK1 is critical for the survival of cardiac myocytes during oxidative stress by regulating the JNK pathway and inhibiting the production of proapoptotic cytokines like TNF-alpha.

Cite This Study

Minamino et al. (1999) studied this question.

synapsesocial.com/papers/6a8ad7267239707559be97ae https://doi.org/10.1073/pnas.96.26.15127

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MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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