Key result
Right-sided pneumonectomy leading to decompensated pulmonary heart significantly decreased the nuclear-cytoplasmic ratio in right ventricle cardiomyocytes from 0.140 to 0.114.
Absolute Event Rate: 0.114% vs 0.14%
p-value: p=<0.001
In a rat model of cor pulmonale, significant alterations in nuclear-cytoplasmic ratios occur in cardiomyocytes and endotheliocytes, particularly in the right ventricle during decompensation, indicating disrupted cellular structural homeostasis.
Nuclear-cytoplasmatic relations in the cardiomyocytes and endotheliocytes of the pulmonary heart ventricles have been studied. Relations between nucleus and cytoplasm of the cells of the pulmonary heart ventricles changed considerably which is indicative of disorders of the cellular structural homeostasis. The most pronounced changes of the nuclear-cytoplasmic relations are found in right ventricle of the decompensated pulmonary heart.
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Hnatiuk et al. (2016) studied Pulmonary heart (n=35). Right-sided pneumonectomy vs. Intact healthy rats was evaluated on Nuclear-cytoplasmic ratio in right ventricle cardiomyocytes (p=<0.001). Right-sided pneumonectomy leading to decompensated pulmonary heart significantly decreased the nuclear-cytoplasmic ratio in right ventricle cardiomyocytes from 0.140 to 0.114.
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