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Dialkyl phosphonates add in a 1,2 fashion to the C = N bond in 5,5‐dimethyl‐3‐thiozolines 2 to form dialkyl rac‐(4‐thiazolidinyl)phosphonates 3a – e. Upon hydrolysis of 3a rac‐(1‐amino‐2‐mercapto‐2‐methylpropyl)phosphonic acid (4a), the phosphonic acid analog of penicillamine (1), is formed.
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Drauz et al. (1985) studied this question.
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