Key result
Microalbuminuria in patients with type 2 diabetes mellitus was associated with significantly higher levels of oxidative stress compared to normoalbuminuria.
Why the study?
An imbalance between oxidant and antioxidants is thought to precede renal lesions, but the relationship between oxidative markers and microalbuminuria severity in type 2 diabetes mellitus needed evaluation.
Is there a relationship between oxidative stress markers and the severity of microalbuminuria in patients with type 2 diabetes mellitus?
Observational (n=100)
Is there a relationship between oxidative stress markers and the severity of microalbuminuria in patients with type 2 diabetes mellitus?
Oxidative stress is significantly correlated with microalbuminuria in type 2 diabetes, suggesting it may be an important mediator of end-stage renal disease.
An imbalance between oxidant and antioxidants is thought to precede the development of renal lesions. The aim of present study is to determine the relationship between oxidative markers and severity of microalbuminuria in patients with type 2 diabetes mellitus (T2DM). A total of 100 T2DM patients (50 males and 50 females) participated in this study. They were screened for microalbuminuria along with oxidative status in patients. Microalbuminuria was detected by measuring the albumin to creatinine ratio (ACR) in urine samples. Patients were divided into two groups; normoalbuminuria (n=36) and microalbuminuria (n=64) as per the ACR levels. No difference in the groups was observed in terms of age, sex, glycated hemoglobin (HbA1c) and blood pressure. The level of oxidative stress was significantly higher in microalbuminuria group of T2DM patients. A significant correlation was observed between ACR and lipid peroxidation (MDA) levels. We conclude that oxidative stress is one of the important mediators of end-stage renal disease (ESRD).
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Balyan et al. (2020) conducted an observational in Type 2 diabetes mellitus (n=100). Microalbuminuria vs. Normoalbuminuria was evaluated on Oxidative stress levels and correlation between ACR and lipid peroxidation (MDA). Microalbuminuria in patients with type 2 diabetes mellitus was associated with significantly higher levels of oxidative stress compared to normoalbuminuria.
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