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July 22, 2025Cureus2 citationsOpen Access

Intersection of Autonomic Dysfunction and Parkinson’s Disease: Insights Into Neurogenic and Classical Orthostatic Hypotension

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Population

Patients with Parkinson's disease experiencing autonomic dysfunction, specifically neurogenic orthostatic…

Design

Review

Key result

Neurogenic and classical orthostatic hypotension are prevalent non-motor manifestations of Parkinson's disease that require individualized management combining non-pharmacologic and pharmacologic strategies.

Authors

JRJamir Pitton RissardoMRMasoumeh RashidiFRFatemeh Rashidi

Discussion

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Overview

Lacks integrated consensus on nOH/OH in PD; leaves open need for updated guidelines before practice change.

Structured PICO

P
Population
Patients with Parkinson's disease (PD) experiencing autonomic dysfunction, specifically neurogenic orthostatic hypotension (nOH) and classical orthostatic hypotension (OH).

This review highlights the high prevalence of orthostatic hypotension in Parkinson's disease and emphasizes the need for tailored non-pharmacologic and pharmacologic management strategies.

Limitations

  • Definitions of orthostatic hypotension used in the reviewed studies varied.
  • Sample sizes of the included epidemiological studies were relatively small, making it difficult to draw firm conclusions about prevalence.
  • Lack of a comprehensive consensus integrating recent advances in pathophysiology, diagnostic tools, and personalized treatment.

Cite This Study

Rissardo et al. (2025) conducted a review in Parkinson's disease and orthostatic hypotension. Orthostatic hypotension management was evaluated. Neurogenic and classical orthostatic hypotension are prevalent non-motor manifestations of Parkinson's disease that require individualized management combining non-pharmacologic and pharmacologic strategies.

synapsesocial.com/papers/6a8adf83b676b7d1a2fb424ahttps://doi.org/10.7759/cureus.88487
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