Key result
Low-dose intrathecal morphine significantly reduced postoperative fentanyl consumption over 24 hours compared to bupivacaine alone and control (175 μg vs 350 μg and 425 μg, respectively; p=0.0001).
Why the study?
Does intrathecal low-dose morphine and bupivacaine improve postoperative analgesia and reduce stress markers in female patients undergoing total laparoscopic hysterectomy?
Population
47 American Society of Anesthesiologists I–II female patients scheduled for elective total laparoscopic…
Comparison
Subarachnoid block with 5 mg of bupivacaine and… vs Subarachnoid block with 5 mg of bupivacaine only…
Design
RCT, Randomized into 3 groups, Double-blind
Follow-up
24 hours
Authors
Loading...
Supports low-dose intrathecal morphine for opioid-sparing analgesia in gynecologic surgery; confirms efficacy in an RCT.
RCT (n=47)
Double-blind
randomized into 3 groups
Does intrathecal low-dose morphine and bupivacaine improve postoperative analgesia and reduce stress markers in female patients undergoing total laparoscopic hysterectomy?
Absolute Event Rate: 175% vs 425%
p-value: p=0.0001
Preinduction administration of low-dose intrathecal morphine provides better postoperative analgesia up to 24 hours, reducing parenteral opioid consumption and surgical stress in patients undergoing laparoscopic hysterectomy.
Selvam et al. (2018) conducted an RCT in Total laparoscopic hysterectomy (n=47). Low-dose intrathecal morphine vs. Bupivacaine alone (5 mg) or skin infiltration with local anesthetic alone was evaluated on Total postoperative fentanyl consumption during 24 hours of observation (p=0.0001). Low-dose intrathecal morphine significantly reduced postoperative fentanyl consumption over 24 hours compared to bupivacaine alone and control (175 μg vs 350 μg and 425 μg, respectively; p=0.0001).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: