What question did this study set out to answer?

To evaluate and compare the durability of antibody and T-cell responses from peak immunity through 8 months following mRNA or Ad26.COV2.S vaccination.

October 15, 2021New England Journal of MedicineOpen Access

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

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Implication

Longitudinal evaluation demonstrates differential antibody and T-cell kinetics in vaccine recipients through eight months, highlighting distinct durability patterns between platforms.

Key Points

To evaluate and compare the durability of antibody and T-cell responses from peak immunity through 8 months following mRNA or Ad26.COV2.S vaccination.
Monitored humoral antibody and cellular T-cell immune responses over an 8-month follow-up period.
Evaluated responses from peak immunity, defined as 2 to 4 weeks after the second dose for mRNA vaccines or 2 to 4 weeks after a single dose for the Ad26.COV2.S vaccine.
Tracked distinct longitudinal kinetic profiles and waning trajectories of circulating antibodies between mRNA and adenoviral vector vaccine platforms.
Characterized differential persistence and maintenance of cellular T-cell immunity from initial peak levels to 8 months post-immunization.

Cite This Study

A 2021 study studied this question.

synapsesocial.com/papers/6a8ae01f210b9ed19c893185 https://doi.org/10.1056/nejmc2115596

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Implication

Longitudinal evaluation demonstrates differential antibody and T-cell kinetics in vaccine recipients through eight months, highlighting distinct durability patterns between platforms.