Why the study?
Does ADP-induced platelet aggregation differ between patients with unstable angina and normal healthy subjects?
Does ADP-induced platelet aggregation differ between patients with unstable angina and normal healthy subjects?
Platelets from patients with unstable angina show increased sensitivity to ADP-induced aggregation compared to healthy controls, suggesting its potential as a prognostic indicator.
May reflect platelet hyperreactivity in unstable angina; hypothesis-generating for prognostic use, needs prospective validation.
ADP-induced platelet aggregation of normal individuals and of patients with unstable angina were studied. Abnormalities of platelet function included increased aggregability. The ADP concentration required for half-maximal aggregation was significantly lower (4.28±0.30μM) in the unstable angina patients compared with that for normal individuals (5.24±0.15μM). The results are suggestive of platelet aggregation as a useful prognostic indicator for unstable angina.
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Viswanathan et al. (1994) studied this question.
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