Sympathetic overactivity due to sleep fragmentation is associated with elevated diurnal systolic blood pressure in healthy elderly subjects: the PROOF-SYNAPSE study
Key result
Sleep fragmentation, expressed by the autonomic arousal index, was associated with a higher risk for 24-hour systolic hypertension (OR 1.70; 95% CI 1.04-2.80; P=0.036) in healthy elderly subjects.
Why the study?
Is sleep fragmentation associated with elevated systolic blood pressure in healthy elderly subjects?
Population
780 healthy elderly volunteers, mean age 68.7 years, 57.4% women, free of known sleep-disordered breathing…
Design
Cross-sectional
Authors
Discussion
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Implication
May support sleep assessment in elderly BP evaluation; leaves open causality and clinical utility pending prospective data.
Study Design
Type
Observational (n=780)
Structured PICO
Is sleep fragmentation associated with elevated systolic blood pressure in healthy elderly subjects?
P
Population
780 healthy elderly volunteers (mean age 68.7 years, 57.4% women) free of known sleep-disordered breathing, coronary heart disease, and neurological disorders.
E
Exposure
Sleep fragmentation assessed by autonomic arousal index (AAI) derived from pulse transit time.
O
Outcome
Diurnal and 24 h systolic blood pressure, and risk for 24 h systolic hypertension.surrogate
Main Result
Odds Ratio: 1.7 (95% CI 1.04–2.8)
p-value: p=0.036
Repetitive sympathetic arousals during sleep are independently associated with elevated systolic blood pressure and a higher risk of hypertension in healthy elderly individuals.
Cite This Study
Chouchou et al. (2013) conducted an observational in Healthy elderly subjects (n=780). Sleep fragmentation (autonomic arousal index) was evaluated on 24 h systolic hypertension (OR 1.70, 95% CI 1.04-2.80, p=0.036). Sleep fragmentation, expressed by the autonomic arousal index, was associated with a higher risk for 24-hour systolic hypertension (OR 1.70; 95% CI 1.04-2.80; P=0.036) in healthy elderly subjects.