Cardiac Biomarkers and Risk of Atrial Fibrillation in Chronic Kidney Disease: The CRIC Study
Key result
Higher baseline NT-proBNP (HR 2.11; 95% CI 1.75-2.55) and high-sensitivity troponin T (HR 1.42; 95% CI 1.20-1.68) were associated with incident atrial fibrillation in chronic kidney disease.
Why the study?
The study tested associations of cardiac biomarkers of myocardial stretch, injury, inflammation, and fibrosis with the risk of incident AF in chronic kidney disease patients.
Are higher baseline levels of cardiac biomarkers associated with an increased risk of incident atrial fibrillation in patients with chronic kidney disease?
Study Design
Type
Cohort (n=3,053)
Multicenter
Yes
Structured PICO
Are higher baseline levels of cardiac biomarkers associated with an increased risk of incident atrial fibrillation in patients with chronic kidney disease?
P
Population
3,053 participants with chronic kidney disease and no baseline atrial fibrillation, followed for a median of 8 years.
E
Exposure
Higher baseline levels of cardiac biomarkers (NT-proBNP, high-sensitivity troponin T, galectin-3, growth differentiation factor-15, and soluble ST-2)
O
Outcome
Incident atrial fibrillation (defined as a hospitalization for AF)hard clinical
Main Result
Hazard Ratio: 2.11 (95% CI 1.75–2.55)
Elevated baseline levels of NT-proBNP and high-sensitivity troponin T are strongly associated with an increased risk of incident atrial fibrillation in patients with chronic kidney disease.
Authors
Discussion
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Implication
May aid AF risk stratification in CKD; leaves open whether biomarkers improve prediction or guide interventions.
Cite This Study
Lamprea‐Montealegre et al. (2019) conducted a cohort in chronic kidney disease (n=3,053). Higher baseline cardiac biomarkers (NT-proBNP and high-sensitivity troponin T) was evaluated on Incident atrial fibrillation (hospitalization for AF) (HR 2.11, 95% CI 1.75, 2.55). Higher baseline NT-proBNP (HR 2.11; 95% CI 1.75-2.55) and high-sensitivity troponin T (HR 1.42; 95% CI 1.20-1.68) were associated with incident atrial fibrillation in chronic kidney disease.