This report is part of a study of the possible association between certain constitutional traits and susceptibility to leukemia in the Ak strain of mice. This strain, or at least the substrain in our laboratory in Oslo, is characterised by a reduction of the adrenocortical lipid concentration as well as by hyperplasia and delayed physiological involution of the thymus. Law & Speirs (1947) and Law (1947) have demonstrated that the leukemic process is influenced by the adrenal cortex. Furth (1946) showed that the incidence of leukemia in the Ak strain was reduced after thymectomy. It was therefore considered justifiable to study the »adreno-thymic« constitution of the Ak strain in order to test the hypothesis of an association between constitution and susceptibility to leukemia. A preliminary report of this investigation has been published (Arnesen, 1953).
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Kristen Arnesen (1955) studied this question.