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March 28, 2025Frontiers in Human NeuroscienceOpen Access

Six weeks of aerobic exercise significantly reduced anxiety scores (p=0.025) and left frontal theta/beta ratio, whereas resistance exercise significantly reduced depression scores (p=0.044) compared to control.

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Why the study?

Although exercise reduces anxiety and depression symptoms, the disparate effects of specific exercise modalities on mood symptoms and electroencephalography activity remain to be elucidated.

Does aerobic and resistance exercise reduce anxiety and depression symptoms and alter EEG activity in healthy adults?

Comparison

Six weeks of aerobic exercise vs resistance exercise with a 3-week washout period

Key result

Six weeks of aerobic exercise significantly reduced anxiety scores (p=0.025) and left frontal theta/beta ratio, whereas resistance exercise significantly reduced depression scores (p=0.044) compared to control.

Authors

KYKihoon YukJLJawon LimSKSangYun Kim

Discussion

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Overview

Aerobic exercise may preferentially ease anxiety and resistance target depression; leaves open confirmation via larger RCTs with EEG biomarkers.

Study Design

Type

RCT (n=28)

Blinding

Single-blind (assessors blinded to EEG signals)

Randomization

Randomly divided into three groups

Multicenter

No

Structured PICO

Does aerobic and resistance exercise reduce anxiety and depression symptoms and alter EEG activity in healthy adults?

P
Population
28 healthy young adults aged 19-39 years, not taking psychiatric medications or exercising regularly, who completed two 6-week exercise interventions separated by a 3-week washout.
I
Intervention
6 weeks of aerobic exercise (cycling at 60-70% heart rate reserve for 30 min, twice a week) and 6 weeks of resistance exercise (3 sets of 10-12 repetitions, twice a week) with a 3-week washout period between each intervention.
C
Comparator
Non-exercise control group.
O
Outcome
Severity of anxiety and depression assessed by the Hospital Anxiety and Depression Scale (HADS), and EEG activity (theta/beta ratio, Higuchi Fractal Dimension, and frontal alpha asymmetry).patient reported

Main Result

p-value: p=0.025 for anxiety (aerobic vs control); 0.044 for depression (resistance vs control)

Aerobic exercise specifically alleviates anxiety symptoms and alters frontal theta/beta ratio, whereas resistance exercise specifically improves depressive symptoms, suggesting the need for personalized exercise prescriptions for mental health.

Limitations

  • Small sample size due to dropouts, resulting in lower statistical power
  • Absence of objective biomarkers to confirm the adequacy of the 3-week washout period
  • Lack of control for confounding lifestyle variables such as diet and sleep patterns
  • Technical limitations regarding EEG analysis, including difficulty controlling impedance with a dry cap and potential signal noise artifacts
  • Participants were not clinically diagnosed as patients with mood disorders, limiting generalizability to clinical populations.

Cite This Study

Yuk et al. (2025) conducted an RCT in Healthy adults (assessing mood-related symptoms) (n=28). Aerobic and resistance exercise vs. Non-exercise control group was evaluated on Change in Hospital Anxiety and Depression Scale (HADS) scores (p=0.025 for anxiety (aerobic vs control); 0.044 for depression (resistance vs control)). Six weeks of aerobic exercise significantly reduced anxiety scores (p=0.025) and left frontal theta/beta ratio, whereas resistance exercise significantly reduced depression scores (p=0.044) compared to control.

synapsesocial.com/papers/6a8ae8655ef9ff12d7892ebfhttps://doi.org/10.3389/fnhum.2025.1562702
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of exercise on mood changes, autonomic function and frontal alpha band lateralization in depressed university students2026
  2. 2Effects of Aerobic Exercise on Anxiety Symptoms and Cortical Activity in Patients with Panic Disorder: A Pilot Study2018 · 27 citations
  3. 3Effect of aerobic training on EEG alpha asymmetry and depressive symptoms in the elderly: a 1-year follow-up study2010 · 87 citations
  4. 4AEROBIC VS RESISTANCE EXERCISE IN THE TREATMENT OF DEPRESSION: A NARRATIVE REVIEW2026
  5. 5Brain activation, affect, and aerobic exercise: An examination of both state‐independent and state‐dependent relationships1997 · 75 citations